SÜPER MEYVELERDEKİ BİYOAKTİF BİLEŞENLERİN SAĞLIK ETKİLERİNİN DEĞERLENDİRİLMESİ

Alam, M., Rashid, S., Fatima, K., Adnan, M., Shafie, A., Akhtar, M. S., Ganie, A. H., Eldin, S. M., Islam, A., Khan, I., & Hassan, M. I. (2023). Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits. Biomedicine & Pharmacotherapy, 163, 114710. https://doi.org/10.1016/j.biopha.2023.114710

Anantachoke, N., Lomarat, P., Praserttirachai, W., Khammanit, R., & Mangmool, S. (2016). Thai Fruits Exhibit Antioxidant Activity and Induction of Antioxidant Enzymes in HEK-293 Cells. Evidence-Based Complementary and Alternative Medicine: ECAM, 2016. https://doi.org/10.1155/2016/6083136

Banjari, I., Misir, A., Šavikin, K., Jokić, S., Molnar, M., De Zoysa, H. K. S., & Waisundara, V. Y. (2017). Antidiabetic Effects of Aronia melanocarpa and Its Other Therapeutic Properties. Frontiers in Nutrition, 4, 53. https://doi.org/10.3389/fnut.2017.00053/full

Banwo, K., Olojede, A. O., Adesulu-Dahunsi, A. T., Verma, D. K., Thakur, M., Tripathy, S., Singh, S., Patel, A. R., Gupta, A. K., & Aguilar, C. N. (2021). Functional importance of bioactive compounds of foods with potential health benefits: A review on recent trends. Food Bioscience, 43, 101320. https://doi.org/10.1016/j.fbio.2021.101320

Belwal, T., Devkota, H. P., Hassan, H. A., Ahluwalia, S., Ramadan, M. F., Mocan, A., & Atanasov, A. G. (2018). Phytopharmacology of Acerola (Malpighia spp.) and its potential as functional food. Trends in Food Science & Technology, 74, 99–106. https://doi.org/10.1016/j.tifs.2018.01.014

Borowska, S., & Brzóska, M. M. (2016). Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics. Comprehensive Reviews in Food Science and Food Safety, 15(6), 982–1017. https://doi.org/10.1111/1541-4337.12221

Chang, S. K., Alasalvar, C., & Shahidi, F. (2019). Superfruits: Phytochemicals, antioxidant efficacies, and health effects—A comprehensive review. Critical Reviews in Food Science and Nutrition, 59(10), 1580–1604. https://doi.org/10.1080/10408398.2017.1422111

Chavan, T., & Muth, A. (2021). The diverse bioactivity of α-mangostin and its therapeutic implications. Future Medicinal Chemistry, 13(19), 1679–1694. https://doi.org/10.4155/fmc-2021-0146

Chen, S. P., Lin, S. R., Chen, T. H., Ng, H. S., Yim, H. S., Leong, M. K., & Weng, C. F. (2021). Mangosteen xanthone γ-mangostin exerts lowering blood glucose effect with potentiating insulin sensitivity through the mediation of AMPK/PPARγ. Biomedicine & Pharmacotherapy, 144, 112333. https://doi.org/10.1016/j.biopha.2021.112333

Cory, H., Passarelli, S., Szeto, J., Tamez, M., & Mattei, J. (2018). The role of polyphenols in human health and food systems: A mini-review. Frontiers in Nutrition, 5, 87. https://doi.org/10.3389/fnut.2018.00087

de Aquino Souza Miskinis, R., do Nascimento, L. Á., & Colussi, R. (2023). Bioactive compounds from acerola pomace: A review. Food Chemistry, 404(Pt A). https://doi.org/10.1016/j.foodchem.2022.134613

Dembitsky, V. M., Poovarodom, S., Leontowicz, H., Leontowicz, M., Vearasilp, S., Trakhtenberg, S., & Gorinstein, S. (2011). The multiple nutrition properties of some exotic fruits: Biological activity and active metabolites. Food Research International, 44(7), 1671–1701. https://doi.org/10.1016/j.foodres.2011.03.003

El-Hawary, S. S., El-Fitiany, R. A., Mousa, O. M., Salama, A. A. A., & El Gedaily, R. A. (2021). Metabolic profiling and in vivo hepatoprotective activity of Malpighia glabra L. leaves. Journal of Food Biochemistry, 45(2). https://doi.org/10.1111/jfbc.13588

Essa, M. M., Bishir, M., Bhat, A., Chidambaram, S. B., Al-Balushi, B., Hamdan, H., Govindarajan, N., Freidland, R. P., & Qoronfleh, M. W. (2023). Functional foods and their impact on health. Journal of Food Science and Technology, 60, 820–834. https://doi.org/10.1007/s13197-021-05193-3

Givens, N. T., Zhao, L., Zhu, Z., Lequio, M., Xiao, H., Johnson, B. D., Bai, Q., Wakefield, M. R., & Fang, Y. (2022). Mangosteen Inhibits Growth and Survival of Cervical Cancer Cells. Anticancer Research, 42(6), 2903–2909. https://doi.org/10.21873/anticanres.15772

Gurčík, Ľ., Bajusová, Z., Ladvenicová, J., Palkovič, J., & Novotná, K. (2023). Cultivation and Processing of Modern Superfood—Aronia melanocarpa (Black Chokeberry) in Slovak Republic. Agriculture 2023, Vol. 13, Page 604, 13(3), 604. https://doi.org/10.3390/agriculture13030604

Gęgotek, A., & Skrzydlewska, E. (2023). Ascorbic acid as antioxidant. Vitamins and Hormones, 121, 247–270. https://doi.org/10.1016/bs.vh.2022.10.008

Jeon, Y. D., Kang, S. H., Moon, K. H., Lee, J. H., Kim, D. G., Kim, W., Kim, J. S., Ahn, B. Y., & Jin, J. S. (2018). The Effect of Aronia Berry on Type 1 Diabetes In Vivo and In Vitro. Journal of Medicinal Food, 21(3), 244–253. https://doi.org/10.1089/jmf.2017.3939

Jurendić, T., & Ščetar, M. (2021). Aronia melanocarpa Products and By-Products for Health and Nutrition: A Review. Antioxidants, 10(7). https://doi.org/10.3390/antiox10071052

Kalick, L. S., Khan, H. A., Maung, E., Baez, Y., Atkinson, A. N., Wallace, C. E., Day, F., Delgadillo, B. E., Mondal, A., Watanapokasin, R., Barbalho, S. M., & Bishayee, A. (2023). Mangosteen for malignancy prevention and intervention: Current evidence, molecular mechanisms, and future perspectives. Pharmacological Research, 188, 106630. https://doi.org/10.1016/j.phrs.2022.106630

Kasprzak-Drozd, K., Oniszczuk, T., Soja, J., Gancarz, M., Wojtunik-Kulesza, K., Markut-Miotła, E., & Oniszczuk, A. (2021). The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases. International Journal of Molecular Sciences, 22(12). https://doi.org/10.3390/ijms22126541

Klosterhoff, R. R., Bark, J. M., Glänzel, N. M., Iacomini, M., Martinez, G. R., Winnischofer, S. M. B., & Cordeiro, L. M. C. (2018). Structure and intracellular antioxidant activity of pectic polysaccharide from acerola (Malpighia emarginata). International Journal of Biological Macromolecules, 106, 473–480. https://doi.org/10.1016/j.ijbiomac.2017.08.032

Lakmal, K., Yasawardene, P., Jayarajah, U., & Seneviratne, S. L. (2021). Nutritional and medicinal properties of Star fruit (Averrhoa carambola): A review. Food Science & Nutrition, 9(3), 1810–1823. https://doi.org/10.1002/fsn3.2135

Lang, Y., Gao, N., Zang, Z., Meng, X., Lin, Y., Yang, S., Yang, Y., Jin, Z., & Li, B. (2024). Classification and antioxidant assays of polyphenols: A review. Journal of Future Foods, 4(3), 193–204. https://doi.org/10.1016/j.jfutfo.2023.07.002

Leffa, D. D., Rezin, G. T., Daumann, F., Longaretti, L. M., Dajori, A. L. F., Gomes, L. M., Silva, M. C., Streck, E. L., & de Andrade, V. M. (2017). Effects of Acerola (Malpighia emarginata DC.) Juice Intake on Brain Energy Metabolism of Mice Fed a Cafeteria Diet. Molecular Neurobiology, 54(2), 954–963. https://doi.org/10.1007/s12035-016-9691-y

Leffa, D. D., Valvassori, S. S., Varela, R. B., Lopes-Borges, J., Daumann, F., Longaretti, L. M., Dajori, A. L. F., Quevedo, J., & Andrade, V. M. (2015). Effects of palatable cafeteria diet on cognitive and noncognitive behaviors and brain neurotrophins’ levels in mice. Metabolic Brain Disease, 30(4), 1073–1082. https://doi.org/10.1007/s11011-015-9682-0

Liu, J. Q., Deng, Y. Y., Li, T. Z., Han, Q., Li, Y., & Qiu, M. H. (2014). Three new tetranorditerpenes from aerial parts of acerola cherry (Malpighia emarginata). Molecules (Basel, Switzerland), 19(2), 2629–2636. https://doi.org/10.3390/molecules19022629

Loo, B. M., Erlund, I., Koli, R., Puukka, P., Hellström, J., Wähälä, K., Mattila, P., & Jula, A. (2016). Consumption of chokeberry (Aronia mitschurinii) products modestly lowered blood pressure and reduced low-grade inflammation in patients with mildly elevated blood pressure. Nutrition Research (New York, N.Y.), 36(11), 1222–1230. https://doi.org/10.1016/j.nutres.2016.09.005

Lorenz, E. C., Michet, C. J., Milliner, D. S., & Lieske, J. C. (2013). Update on oxalate crystal disease. Current Rheumatology Reports, 15(7). https://doi.org/10.1007/s11926-013-0340-4

Lu, S., Zhang, H., Wei, X., Huang, X., Chen, L., Jiang, L., Wu, X., Zhou, X., Qin, L., Li, Y., Lin, X., & Huang, R. (2019). 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione isolated from Averrhoa carambola L. root ameliorates diabetic nephropathy by inhibiting the TLR4/MyD88/NF-κB pathway. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 12, 1355–1363. https://doi.org/10.2147/dmso.s209436

Luan, F., Peng, L., Lei, Z., Jia, X., Zou, J., Yang, Y., He, X., & Zeng, N. (2021). Traditional Uses, Phytochemical Constituents and Pharmacological Properties of Averrhoa carambola L.: A Review. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.699899

Marques, T. R., Caetano, A. A., Henrique S. Cesar, P., Braga, M. A., Henrique A. Machado, G., de Sousa, R. V., & Corrêa, A. D. (2018). Antioxidant activity and hepatoprotective potential of lyophilized extract of acerola bagasse against CCl4-induced hepatotoxicity in Wistar rats. Journal of Food Biochemistry, 42(6), e12670. https://doi.org/10.1111/jfbc.12670

Naruszewicz, M., Łaniewska, I., Millo, B., & Dłuzniewski, M. (2007). Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI). Atherosclerosis, 194(2), e179–e184. https://doi.org/10.1016/j.atherosclerosis.2006.12.032

Nauman, M. C., & Johnson, J. J. (2022). The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones. Pharmacological Research, 175, 106032. https://doi.org/10.1016/j.phrs.2021.106032

Nicolescu, A., Babotă, M., Zhang, L., Bunea, C. I., Gavrilă, A. M., Vodnar, D. C., Rocchetti, G., & Crișan, G. (2023). Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods. Frontiers in Nutrition, 10, 1184535. https://doi.org/10.3389/fnut.2023.1184535

Olędzki, R., & Harasym, J. (2024). Acerola (Malpighia emarginata) Anti-Inflammatory Activity—A Review. International Journal of Molecular Sciences, 25(4). https://doi.org/10.3390/ijms25042089

Ovalle-Magallanes, B., Eugenio-Pérez, D., & Pedraza-Chaverri, J. (2017). Medicinal properties of mangosteen (Garcinia mangostana L.): A comprehensive update. Food and Chemical Toxicology, 109, 102–122. https://doi.org/10.1016/j.fct.2017.08.021

Ovaskainen, M. L., Törrönen, R., Koponen, J. M., Sinkko, H., Hellström, J., Reinivuo, H., & Mattila, P. (2008). Dietary intake and major food sources of polyphenols in Finnish adults. The Journal of Nutrition, 138(3), 562–566. https://doi.org/10.1093/jn/138.3.562

Paz, M., Gúllon, P., Barroso, M. F., Carvalho, A. P., Domingues, V. F., Gomes, A. M., Becker, H., Longhinotti, E., & Delerue-Matos, C. (2015). Brazilian fruit pulps as functional foods and additives: Evaluation of bioactive compounds. Food Chemistry, 172, 462–468. https://doi.org/10.1016/j.foodchem.2014.09.102

Pham, H. T. T., Huang, W., Han, C., Li, J., Xie, Q., Wei, J., Xu, X., Lai, Z., Huang, X., Huang, R. Bin, & Wen, Q. W. (2017). Effects of Averrhoa carambola L. (Oxalidaceae) juice mediated on hyperglycemia, hyperlipidemia, and its influence on regulatory protein expression in the injured kidneys of streptozotocin-induced diabetic mice. American Journal of Translational Research, 9(1), 36. https://pmc.ncbi.nlm.nih.gov/articles/PMC5250702/

Phyu, M. P., & Tangpong, J. (2014). Neuroprotective effects of xanthone derivative of Garcinia mangostana against lead-induced acetylcholinesterase dysfunction and cognitive impairment. Food and Chemical Toxicology, 70, 151–156. https://doi.org/10.1016/j.fct.2014.04.035

Poletto, P., Álvarez-Rivera, G., López, G. D., Borges, O. M. A., Mendiola, J. A., Ibáñez, E., & Cifuentes, A. (2021). Recovery of ascorbic acid, phenolic compounds and carotenoids from acerola by-products: An opportunity for their valorization. LWT, 146, 111654. https://doi.org/10.1016/j.lwt.2021.111654

Ren, Y., Frank, T., Meyer, G., Lei, J., Grebenc, J. R., Slaughter, R., Gao, Y. G., & Kinghorn, A. D. (2022). Potential Benefits of Black Chokeberry (Aronia melanocarpa) Fruits and Their Constituents in Improving Human Health. Molecules, 27(22). https://doi.org/10.3390/molecules27227823

Shi, J., Wang, Y., Liang, T., Wang, X., Xie, J., Huang, R., Xu, X., & Wei, X. (2024). DMDD, isolated from Averrhoa carambola L., ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-autophagy crosstalk. Chinese Medicine, 19, 125. https://doi.org/10.1186/s13020-024-00993-z

Sidor, A., & Gramza-Michałowska, A. (2019). Black Chokeberry Aronia Melanocarpa L.—A Qualitative Composition, Phenolic Profile and Antioxidant Potential. Molecules 2019, Vol. 24, Page 3710, 24(20), 3710. https://doi.org/10.3390/molecules24203710

Souza, N. C., de Oliveira Nascimento, E. N., de Oliveira, I. B., Oliveira, H. M. L., Santos, E. G. P., Moreira Cavalcanti Mata, M. E. R., Gelain, D. P., Moreira, J. C. F., Dalmolin, R. J. S., & de Bittencourt Pasquali, M. A. (2020). Anti-inflammatory and antixidant properties of blend formulated with compounds of Malpighia emarginata D.C (acerola) and Camellia sinensis L. (green tea) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Biomedicine & Pharmacotherapy, 128. https://doi.org/10.1016/j.biopha.2020.110277

Stojković, L., Zec, M., Zivkovic, M., Bundalo, M., Bošković, M., Glibetić, M., & Stankovic, A. (2021). Polyphenol-Rich Aronia melanocarpa Juice Consumption Affects LINE-1 DNA Methylation in Peripheral Blood Leukocytes in Dyslipidemic Women. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.689055

Suttirak, W., & Manurakchinakorn, S. (2014). In vitro antioxidant properties of mangosteen peel extract. Journal of Food Science and Technology, 51(12), 3546. https://doi.org/10.1007/s13197-012-0887-5

Taher, M., Tg Zakaria, T. M. F. S., Susanti, D., & Zakaria, Z. A. (2016). Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linomn. in normoglycaemic and streptozotocin-induced diabetic rats. BMC Cplementary and Alternative Medicine, 16(1). https://doi.org/10.1186/s12906-016-1118-9

Vemu, B., Nauman, M. C., Veenstra, J. P., & Johnson, J. J. (2019). Structure activity relationship of xanthones for inhibition of Cyclin Dependent Kinase 4 from mangosteen (Garcinia mangostana L.). International Journal of Nutrition, 4(2), 38. https://doi.org/10.14302/issn.2379-7835.ijn-19-2845

Wan, J., Zhou, J., Fu, L., Li, Y., Zeng, H., Xu, X., Lv, C., & Jin, H. (2021). Ascorbic Acid Inhibits Liver Cancer Growth and Metastasis in vitro and in vivo, Independent of Stemness Gene Regulation. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.726015

Wang, L., Wang, R., Dong, J., Wang, Y., Huang, X., & Chen, C. (2023). Research on the extraction, purification and determination of chemical components, biological activities, and applications in diet of black chokeberry (Aronia melanocarpa). Chinese Journal of Analytical Chemistry, 51(10), 100301. https://doi.org/10.1016/j.cjac.2023.100301

Wang, M. H., Zhang, K. J., Gu, Q. L., Bi, X. L., & Wang, J. X. (2017). Pharmacology of mangostins and their derivatives: A comprehensive review. Chinese Journal of Natural Medicines, 15(2), 81–93. https://doi.org/10.1016/s1875-5364(17)30024-9

World Health Organization. (2025). Noncommunicable diseases. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases

World Health Organization. (2026). Healthy diet. https://www.who.int/news-room/fact-sheets/detail/healthy-diet

Xie, L., Vance, T., Kim, B., Lee, S. G., Caceres, C., Wang, Y., Hubert, P. A., Lee, J. Y., Chun, O. K., & Bolling, B. W. (2017). Aronia berry polyphenol consumption reduces plasma total and low-density lipoprotein cholesterol in former smokers without lowering biomarkers of inflammation and oxidative stress: a randomized controlled trial. Nutrition Research (New York, N.Y.), 37, 67–77. https://doi.org/10.1016/j.nutres.2016.12.007

Yamaguchi, K. K. D. L., Pereira, L. F. R., Lamarão, C. V., Lima, E. S., & Da Veiga-Junior, V. F. (2015). Amazon acai: Chemistry and biological activities: A review. Food Chemistry, 179, 137–151. https://doi.org/10.1016/j.foodchem.2015.01.055

Yamane, T., Kozuka, M., Wada-Yoneta, M., Sakamoto, T., Nakagaki, T., Nakano, Y., & Ohkubo, I. (2017). Aronia juice suppresses the elevation of postprandial blood glucose levels in adult healthy Japanese. Clinical Nutrition Experimental, 12, 20–26. https://doi.org/10.1016/j.yclnex.2017.01.002

Yasawardene, P., Jayarajah, U., De Zoysa, I., & Seneviratne, S. L. (2020). Mechanisms of star fruit (Averrhoa carambola) toxicity: A mini-review. Toxicon : Official Journal of the International Society on Toxinology, 187, 198–202. https://doi.org/10.1016/j.toxicon.2020.09.010

Yasawardene, P., Jayarajah, U., De Zoysa, I., & Seneviratne, S. L. (2021). Nephrotoxicity and neurotoxicity following star fruit (Averrhoa carambola) ingestion: A narrative review. Transactions of the Royal Society of Tropical Medicine and Hygiene, 115(9), 947–955. https://doi.org/10.1093/trstmh/trab026

Zima, K., Khaidakov, B., Banaszkiewicz, L., Lemke, K., & Kowalczyk, P. K. (2024). Exploring the Potential of Ribes nigrum L., Aronia melanocarpa (Michx.) Elliott, and Sambucus nigra L. Fruit Polyphenol-Rich Composition and Metformin Synergy in Type 2 Diabetes Management. Journal of Diabetes Research, 2024(1). https://doi.org/10.1155/2024/1092462