İRRİTABL BAĞIRSAK SENDROMU TANISINDA KULLANILAN BİYOKİMYASAL BELİRTEÇLER
Özet
İrritabl bağırsak sendromu (İBS) kadınlarda daha sık görülen, patolojisi tam olarak bilinmeyen bir hastalıktır. İBS’nin dışkılamayla ilişkili değişiklikler ve karın ağrısı ile karakterize olduğu, beyin-bağırsak etkileşimi bozukluğu sonucu ortaya çıktığı düşünülmektedir. İBS dünya çapında her 10 kişiden birini etkilemektedir. Hastalık; stres, enfeksiyon geçirme, bağışıklık sisteminin bozulması, visseral aşırı duyarlılık veya genetik bir defektten kaynaklanabilmektedir. İBS, semptomlarına göre alt tiplere ayrılmaktadır: Kabızlığın baskın olduğu (İBS-C), diyarenin baskın olduğu (İBS-D) ve her ikisinin birden görülebildiği karma (İBS-M) alt tipleri mevcuttur. Hastalarda tespit edilen bu baskın bağırsak alışkanlıklarına göre uygun tedavi yöntemi belirlenmelidir.
Hastalığın yönetimi için çeşitli yöntemler uygulansa da ilk amaç tanı sürecinin etkinliğini ve doğruluğunu artırmaktır. Günümüzde İBS’nin tanısı için spesifik bir biyobelirteç bulunmamaktadır. İBS şüphesi olan hastalara tam kan sayımı, IgA, CRP, fekal kalprotektin, TSH, sitokin ve kemokin ölçümleri yapılmaktadır. Bu biyolojik parametrelere ek olarak, tanı sürecini kolaylaştıracak spesifik biyobelirteçlerin keşfi büyük önem taşımaktadır.
Anahtar Kelimeler: İrritabl Bağırsak Sendromu, Biyobelirteç, CRP, Fekal kalprotektin
Konu Alanı: Tıp -> Tıp (diğer) -> Biyokimya (tıbbi)
Adriani, A., Ribaldone, D. G., Astegiano, M., Durazzo, M., Saracco, G. M., & Pellicano, R. (2018). Irritable bowel syndrome: the clinical approach. Panminerva Medica, 60(4), 213-222.
Altobelli, E., Del Negro, V., Angeletti, P. M., & Latella, G. (2017). Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis. Nutrients, 9(9), 940.
Camilleri, M. (2018). Management options for irritable bowel syndrome. Mayo Clinic Proceedings, 93(12), 1858-1872.
Canavan, C., West, J., & Card, T. (2014). The epidemiology of irritable bowel syndrome. Clinical Epidemiology, 6, 71-80.
Carter, K. A. (2024). Irritable bowel syndrome: Clinical practice update. Journal of the American Association of Nurse Practitioners, 37(1), 13-18.
Chey, W. D., Hashash, J. G., Manning, L., & Chang, L. (2022). AGA Clinical Practice Update on the Role of Diet in Irritable Bowel Syndrome: Expert Review. Gastroenterology, 162(6), 1737-1745.e5.
Chey, W. D., Kurlander, J., & Eswaran, S. (2015). Irritable bowel syndrome: a clinical review. JAMA, 313(9), 949-958.
Curtin, B., Jimenez, E., & Rao, S. S. (2020). Clinical Evaluation of a Patient With Symptoms of Colonic or Anorectal Motility Disorders. Journal of Neurogastroenterology and Motility, 26(4), 423-436.
Drossman, D. A. (2016). Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV. Gastroenterology, 150(6), 1262-1279.e2.
Enck, P., & Mazurak, N. (2018). Dysbiosis in functional bowel disorders. Annals of Nutrition and Metabolism, 72(4), 296-306.
Fond, G., Loundou, A., Hamdani, N., Boukouaci, W., Dargel, A., Oliveira, J., Roger, M., Tamouza, R., Leboyer, M., & Boyer, L. (2014). Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. European Archives of Psychiatry and Clinical Neuroscience, 264(8), 651-660.
Ford, A. C., Forman, D., Bailey, A. G., Axon, A. T., & Moayyedi, P. (2008). Irritable bowel syndrome: a 10-yr natural history of symptoms and factors that influence consultation behavior. The American Journal of Gastroenterology, 103(5), 1229-1239.
Ford, A. C., Moayyedi, P., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M., & Quigley, E. M. (2014). American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. The American Journal of Gastroenterology, 109, S2-S26.
Goldstein, R. S., & Cash, B. D. (2021). Making a confident diagnosis of irritable bowel syndrome. Gastroenterology Clinics of North America, 50(3), 547-563.
Hayes, P. A., Fraher, M. H., & Quigley, E. M. (2014). Irritable bowel syndrome: the role of food in pathogenesis and management. Gastroenterology & Hepatology, 10(3), 164.
Henningsen, P., Zimmermann, T., & Sattel, H. (2003). Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review. Psychosomatic Medicine, 65(4), 528-533.
Jiang, J., Chen, Y., Hu, Z., Li, H., Ye, J., Yu, Z., & Tang, H. (2021). Effectiveness of Tong-Xie-Yao-Fang combined with Si-Ni-San for irritable bowel syndrome: A protocol for systematic review and meta-analysis. Medicine, 100(15), e25198.
Kay, E., Hawramee, S., Pollani, S., & Mandel, E. D. (2019). Nonpharmacologic options for treating irritable bowel syndrome. Journal of the American Academy of PAs, 32(9), 38-42.
Koloski, N. A., Jones, M., & Talley, N. J. (2016). Evidence that independent gut‐to‐brain and brain‐to‐gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1‐year population‐based prospective study. Alimentary Pharmacology & Therapeutics, 44(6), 592-600.
Koloski, N. A., Jones, M., Kalantar, J., Weltman, M., Zaguirre, J., & Talley, N. J. (2012). The brain–gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study. Gut, 61(9), 1284-1290.
Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016). Bowel disorders. Gastroenterology, 150(6), 1393-1407.e5.
Lacy, B. E., Pimentel, M., Brenner, D. M., Chey, W. D., Keefer, L. A., Long, M. D., & Moshiree, B. (2021). ACG Clinical Guideline: Management of Irritable Bowel Syndrome. The American Journal of Gastroenterology, 116(1), 17-44.
Liebregts, T., Adam, B., Bertel, A., Jones, S., Schulze, J., Enders, C., Sonnenborn, U., Lackner, K., & Holtmann, G. (2005). Effect of E. coli Nissle 1917 on post‐inflammatory visceral sensory function in a rat model. Neurogastroenterology & Motility, 17(3), 410-414.
Macsharry, J., O'Mahony, L., Fanning, A., Bairead, E., Sherlock, G., Tiesman, J., Fulmer, A., Kiely, B., Dinan, T. G., & Shanahan, F. (2008). Mucosal cytokine imbalance in irritable bowel syndrome. Scandinavian Journal of Gastroenterology, 43(12), 1467-1476.
Martínez, C., Lobo, B., Pigrau, M., Ramos, L., González-Castro, A. M., Alonso, C., Guilarte, M., Guilá, M., De Torres, I., & Azpiroz, F. (2013). Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut, 62(8), 1160-1168.
Nelkowska, D. D. (2020). Treating irritable bowel syndrome through an interdisciplinary approach. Annals of Gastroenterology, 33(1), 1-8.
Ng, Q. X., Soh, A. Y. S., Loke, W., Lim, D. Y., & Yeo, W. S. (2018). The role of inflammation in irritable bowel syndrome (IBS). Journal of Inflammation Research, 11, 345-349.
Pimentel, M., Talley, N. J., Quigley, E. M., Hani, A., Sharara, A., & Mahachai, V. (2013). Report from the multinational irritable bowel syndrome initiative 2012. Gastroenterology, 144(6), e1-e5.
Quigley, E. M. M., Fried, M., Gwee, K. A., Khalif, I., Hungin, P., Lindberg, G., Abbas, Z., Fernandez, L. B., Bhatia, S. J., Schmulson, M., Olano, C., & Le Mair, A. (2015). Irritable Bowel Syndrome: a Global Perspective. World Gastroenterology Organisation.
Radovanovic-Dinic, B., Tesic-Rajkovic, S., Grgov, S., Petrovic, G., & Zivkovic, V. (2018). Irritable bowel syndrome-from etiopathogenesis to therapy. Basic Medical Sciences, 162.
Rao, S. S. (2018). Rectal Exam: Yes, it can and should be done in a busy practice!. The American Journal of Gastroenterology, 113(5), 635-638.
Riddle, M. S., DuPont, H. L., & Connor, B. A. (2016). ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults. The American Journal of Gastroenterology, 111(5), 602-622.
Rossiyskaya Gastroenterologicheskaya Assotsiatsiya. (2017). Klinicheskiye rekomendatsii Rossiyskoy gastroenterologicheskoy assotsiatsii i assotsiatsii koloproktologov Rossii po diagnostike i lecheniyu bolezni Krona [Russian Gastroenterological Association and Russian Association of Coloproctology clinical guidelines for diagnosis and treatment of Crohn's disease]. Koloproktologiya, (1), 7-29.
Simrén, M., & Tack, J. (2018). New treatments and therapeutic targets for IBS and other functional bowel disorders. Nature Reviews Gastroenterology & Hepatology, 15(10), 589-605.
Sykes, M. A., Blanchard, E. B., Lackner, J., Keefer, L., & Krasner, S. (2003). Psychopathology in irritable bowel syndrome: support for a psychophysiological model. Journal of Behavioral Medicine, 26(4), 361-372.
Trindade, I. A., Melchior, C., Törnblom, H., & Simrén, M. (2022). Quality of life in irritable bowel syndrome: Exploring mediating factors through structural equation modelling. Journal of Psychosomatic Research, 159, 110809.
Wu, Y., Li, Y., Zheng, Q., & Li, L. (2024). The Efficacy of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Nutrients, 16(13), 2114.
Işık, M. & Taşkan Susam, T. (2026). İRRİTABL BAĞIRSAK SENDROMU TANISINDA KULLANILAN BİYOKİMYASAL BELİRTEÇLER. In ÇELİK, N. (Ed.), Tıbbi Biyokimya: Vücudun Sessiz Kodları (pp. 19-39). Vizetek Yayıncılık. https://doi.org/10.54637/vizetek.9786253824129
| Kitap: |
| Yayınevi:
Vizetek Yayıncılık |