İlk Trimester Kanamalarına Güncel Yaklaşım

ACOG, C. (2018). Early pregnancy loss. American College of Obstetricians and Gynecologists, 132, e197-e207.

https://doi.org/10.1097/AOG.0000000000002899

Ahmed, A.E.-R.E.-S., Khalifa, A.E.-S., & Fares, T. (2022). Effect of threatened abortion on fetal growth and premature rupture of membranes. Al-Azhar Medical Journal, 51(2), 861-870.

https://doi.org/10.21608/amj.2022.230454

Albahlol, I.A. (2021). Cervical pregnancy management: An updated stepwise approach and algorithm. Journal of Obstetrics and Gynaecology Research, 47(2), 469-475.

https://doi.org/10.1111/jog.14617

Barraza-Ortega, E., Gómez-Gil, B., García-Gasca, T., Lizárraga, D., Díaz, N., & García-Gasca, A. (2025). The impact of lifestyle on reproductive health: Microbial complexity, hormonal dysfunction, and pregnancy outcomes. International Journal of Molecular Sciences, 26(17), 8574.

https://doi.org/10.3390/ijms26178574

Bollig, K.J., Finlinson, A., Barnhart, K.T., Coutifaris, C., & Schust, D.J. (2023). Evaluation of a new model for human chorionic gonadotropin rise in pregnancies of unknown viability. Obstetrics & Gynecology, 142(1), 139-146.

https://doi.org/10.1097/AOG.0000000000005235

Boyraz, G., & Bozdağ, G. (2013). Pregnancy of unknown location. Journal of the Turkish German Gynecological Association, 14(2), 104.

https://doi.org/10.5152/jtgga.2013.74317

Bracken, M.B., Brinton, L.A., & Hayashi, K. (1984). Epidemiology of hydatidiform mole and choriocarcinoma. Epidemiologic reviews, 6, 52-75.

https://doi.org/10.1093/oxfordjournals.epirev.a036275

Braga, A., Berkowitz, R., & Horowitz, N. (2025). Etiology, natural history, and management of recent advances in molar pregnancy. Obstetrics & Gynecology, 146(4), 451–465.

https://doi.org/10.1097/AOG.0000000000005998

Brim, A.C.S., Barretto, V.R.D., Reis‐Oliveira, J.G., da Silveira de Araújo, R.B., & Romeo, A.C.D.C.B. (2025). Risk factors for ectopic pregnancy occurrence: Systematic review and meta‐analysis. International Journal of Gynecology & Obstetrics, 168(3), 919-932.

https://doi.org/10.1002/ijgo.15965

Carbonnel, M., Pirtea, P., de Ziegler, D., & Ayoubi, J.M. (2021). Uterine factors in recurrent pregnancy losses. Fertility and sterility, 115(3), 538-545.

https://doi.org/10.1016/j.fertnstert.2020.12.003

Casikar, I., Bignardi, T., Riemke, J., Alhamdan, D., & Condous, G. (2010). Expectant management of spontaneous first‐trimester miscarriage: Prospective validation of the ‘2‐week rule’. Ultrasound in Obstetrics and Gynecology: The Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, 35(2), 223-227.

https://doi.org/10.1002/uog.7486

Choi, Y.J., & Kim, S.H. (2025). Evolving perspectives on blood transfusion in obstetric hemorrhage: A narrative review. Korean Journal of Anesthesiology, 79(1), 13-27.

https://doi.org/10.4097/kja.25413

Chu, J.J., Devall, A.J., Beeson, L.E., Hardy, P., Cheed, V., Sun, Y., . . . Jones, L.L. (2020). Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (mifemiso): A randomised, double-blind, placebo-controlled trial. The Lancet, 396(10253), 770-778.

https://doi.org/10.1016/S0140-6736(20)31788-8

Coomarasamy, A., Devall, A.J., Cheed, V., Harb, H., Middleton, L.J., Gallos, I.D., . . . Ogwulu, C.C. (2023). A randomized trial of progesterone in women with bleeding in early pregnancy. New England Journal of Medicine, 380(19), 1815-1824.

https://doi.org/10.1056/NEJMoa1813730

Crochet, J.R., Bastian, L.A., & Chireau, M.V. (2013). Does this woman have an ectopic pregnancy?: The rational clinical examination systematic review. Jama, 309(16), 1722-1729.

https://doi.org/10.1001/jama.2013.3914

Dogra, V., Paspulati, R.M., & Bhatt, S. (2005). First trimester bleeding evaluation. Ultrasound quarterly, 21(2), 69-85.

Eleje, G.U., Ugwu, E.O., Igbodike, E.P., Malachy, D.E., Nwankwo, E.U., Ugboaja, J.O., . . . Nwagha, U.I. (2023). Prevalence and associated factors of recurrent pregnancy loss in nigeria according to different national and international criteria (asrm/eshre vs. Who/rcog). Frontiers in Reproductive Health, 5, 1049711.

https://doi.org/10.3389/frph.2023.1049711

Emmer, R., Ajne, G., & Papadogiannakis, N. (2024). Missed abortion in the 11–21-week period: Fetal autopsy and placental histopathological analysis of 794 cases. European Journal of Obstetrics & Gynecology and Reproductive Biology, 296, 158-162.

https://doi.org/10.1016/j.ejogrb.2024.02.054

Essers, R., Lebedev, I.N., Kurg, A., Fonova, E.A., Stevens, S.J., Koeck, R.M., . . . Nikitina, T.V. (2023). Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss. Nature Medicine, 29(12), 3233-3242.

https://doi.org/10.1038/s41591-023-02645-5

Flanagan, H.C., Duncan, W.C., Lin, C.-J., Spears, N., & Horne, A.W. (2023). Recent advances in the understanding of tubal ectopic pregnancy. Faculty reviews, 12, 26.

https://doi.org/10.12703/r/12-26

Gamal Ahmed Afandy Abotaha, A., Abou-Sekein, A.E.-H., & Mohamed Taha, E.-S. (2022). Correlation between ultrasound parameters and recurrent pregnancy loss in first trimester. Al-Azhar Medical Journal, 51(4), 1935-1944.

https://doi.org/10.21608/amj.2022.255181

Ghaedi, B., Cheng, W., Ameri, S., Abdulkarim, K., Costain, N., Zia, A., & Thiruganasambandamoorthy, V. (2022). Performance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients: A systematic review and meta-analysis. Canadian Journal of Emergency Medicine, 24(6), 611-621.

https://doi.org/10.1007/s43678-022-00428-5

Griebel, C.P., Halvorsen, J., Golemon, T.B., & Day, A.A. (2005). Management of spontaneous abortion. American family physician, 72(7), 1243-1250.

Harish, K., Shwetha, N., & Nalini, N. (2021). Incidence and risk factors associated with ectopic pregnancy: A prospective study. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 10(2), 703-707.

https://doi.org/10.18203/2320-1770.ijrcog20210387

Health, N.I.f., & Excellence, C. (2019). Ectopic pregnancy and miscarriage: Diagnosis and initial management: National Institute for Health and Care Excellence.

Hendriks, E., MacNaughton, H., & MacKenzie, M.C. (2019). First trimester bleeding: Evaluation and management. American family physician, 99(3), 166-174.

Jauniaux, E., Memtsa, M., Johns, J., Ross, J.A., & Jurkovic, D. (2018). New insights in the pathophysiology of complete hydatidiform mole. Placenta, 62, 28-33.

https://doi.org/10.1016/j.placenta.2017.12.008

Joseph, R., & Irvine, L. (2012). Ovarian ectopic pregnancy: Aetiology, diagnosis, and challenges in surgical management. Journal of Obstetrics and Gynaecology, 32(5), 472-474.

https://doi.org/10.1258/om.2011.110007

Joyce, C.M., Fitzgerald, B., McCarthy, T.V., Coulter, J., & O'Donoghue, K. (2022). Advances in the diagnosis and early management of gestational trophoblastic disease. BMJ medicine, 1(1), e000321.

https://doi.org/10.1136/bmjmed-2022-000321

Kirk, E., Bottomley, C., & Bourne, T. (2014). Diagnosing ectopic pregnancy and current concepts in the management of pregnancy of unknown location. Human reproduction update, 20(2), 250-261.

https://doi.org/10.1093/humupd/dmt047

Lee, D., Contreras, M., Robson, S. C., Rodeck, C. H., & Whittle, M. J. (1999). Recommendations for the use of anti-D immunoglobulin for Rh prophylaxis. Transfusion Medicine, 9(1), 93–97.

https://doi.org/10.1046/j.1365-3148.1999.009001093.x

Li, Q., Yin, A., Zhang, M., & Tian, S. (2025). Comparative study of transvaginal ultrasound and magnetic resonance imaging in the diagnosis and classification of cesarean scar pregnancy. Revista da Associação Médica Brasileira, 71(12), e20250952.

https://doi.org/10.1590/1806-9282.20250952

Ludwig, L., Borisovna, K.A.B., & Jamal, P.O.B. (2023). Comparison of efficacy among different therapeutic approaches in ectopic pregnancy. Special Journal of the Medical Academy and other Life Sciences., 1(6).

https://doi.org/10.58676/sjmas.v1i6.38

Magnus, M.C., Wilcox, A.J., Morken, N.-H., Weinberg, C.R., & Håberg, S.E. (2019). Role of maternal age and pregnancy history in risk of miscarriage: Prospective register based study. bmj, 364.

https://doi.org/10.1136/bmj.l869

Mamo, A., & Adkins, K. (2022). Abdominal pregnancy: Pathophysiology, diagnosis, and treatment. Journal of gynecologic surgery, 38(3), 193-196.

https://doi.org/10.1089/gyn.2022.0013

Moon, A., & Shabbir, S. (2021). Pregnancy outcome in women presenting with per vaginal bleeding in first trimester of pregnancy. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 10(2), 439-444.

https://doi.org/10.18203/2320-1770.ijrcog20210056

Mullany, K., Minneci, M., Monjazeb, R., & C. Coiado, O. (2023). Overview of ectopic pregnancy diagnosis, management, and innovation. Women's Health, 19, 17455057231160349.

https://doi.org/10.1177/17455057231160349

Munro, M.G., Salazar, C.A., Bhagavath, B., Emanuel, M.H., Huddleston, H.G., Sobti, D., . . . Martin, C. (2025). The epidemiology, clinical burden, and prevention of intrauterine adhesions (iuas) related to surgically induced endometrial trauma: A systematic literature review and selective meta-analyses. Human reproduction update, 31(6), 588-625.

https://doi.org/10.1093/humupd/dmaf019

Murphy, A.A., Nager, C.W., Wujek, J.J., Kettel, L.M., Torp, V.A., & Chin, H.G. (1992). Operative laparoscopy versus laparotomy for the management of ectopic pregnancy: A prospective trial. Fertility and sterility, 57(6), 1180-1185.

https://doi.org/10.1016/S0015-0282(16)55070-5

No, G.-t.G. (2011). Maternal collapse in pregnancy and the puerperium.

Obstetricians, A.C.o., & Gynecologists. (2018). Acog practice bulletin no. 193: Tubal ectopic pregnancy. Obstetrics and gynecology, 131(3), e91-e103.

https://doi.org/10.1097/AOG.0000000000002560

Obstetricians, A.C.o., & Gynecologists. (2024). Acog clinical practice update: Rh d immune globulin administration after abortion or pregnancy loss at less than 12 weeks of gestation. Obstet. Gynecol, 144, e140-e143.

https://doi.org/10.1097/AOG.0000000000005733

Ojule, J.D., & Ogu, R.N. (2019). Miscarriage and maternal health Complications of pregnancy: IntechOpen.

Organization, W.H. (2022). Towards a supportive law and policy environment for quality abortion care: Evidence brief: World Health Organization.

Papageorgiou, D., Sapantzoglou, I., Prokopakis, I., & Zachariou, E. (2025). Tubal ectopic pregnancy: From diagnosis to treatment. Biomedicines, 13(6), 1465.

https://doi.org/10.3390/biomedicines13061465

Parvin, S., & Ahmed, M. (2023). Medical versus surgical management in early pregnancy failure. Journal of Shaheed Suhrawardy Medical College, 15(2), 21-24.

https://doi.org/10.3329/jssmc.v15i2.81864

Prabhu, M., Louis, J.M., Kuller, J.A., Medicine, S.f.M.-F., & Committee, S.P. (2024). Society for maternal-fetal medicine statement: Rhd immune globulin after spontaneous or induced abortion at less than 12 weeks of gestation. American Journal of Obstetrics and Gynecology, 230(5), B2-B5.

https://doi.org/10.1016/j.ajog.2024.02.288

Preisler, J., Kopeika, J., Ismail, L., Vathanan, V., Farren, J., Abdallah, Y., . . . Gould, D. (2015). Defining safe criteria to diagnose miscarriage: Prospective observational multicentre study. Bmj, 351.

https://doi.org/10.1136/bmj.h4579

Punit, H., & Sharma, K. (2022). Misadventure of an unsafe abortion. Cureus, 14(11).

https://doi.org/10.7759/cureus.31131

Qayyum, H., & Wahab, S. (2025). Frequency of common signs and symptoms of ectopic pregnancy. Insights-J Health Rehabil, 3(3), 9-15.

https://doi.org/10.71000/3vp56j57

Rana, A., Pradhan, N., Gurung, G., & Singh, M. (2004). Induced septic abortion: A major factor in maternal mortality and morbidity. Journal of Obstetrics and Gynaecology Research, 30(1), 3-8.

https://doi.org/10.1111/j.1341-8076.2004.00146.x

Riahi, R., Rahimiforoushani, A., Nourijelyani, K., Sharak, N.A., & Bakhtiyari, M. (2020). Early detection of gestational trophoblastic neoplasia based on serial measurement of human chorionic gonadotrophin hormone in women with molar pregnancy. International Journal of Preventive Medicine, 11(1), 187.

https://doi.org/10.4103/ijpvm.IJPVM_288_19

Salov, I., Naumova, I., & Lomovitskaya, M. (2024). Optimization of intrauterine interventions in spontaneous abortion. Obstetrics, Gynecology and Reproduction, 18(3), 352-364.

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2024.522

Sijabat, L., Prasetya, R.J., & Juliana, M. (2026). What are the most effective management strategies for obstetric emergencies in icu settings, and how do they impact maternal and neonatal mortality rates?: A systematic review. The Indonesian Journal of General Medicine, 34(1), 46-93.

Sileo, F.G., Giuliani, G.A., Facchinetti, F., Contu, G., Chiossi, G., & Bertucci, E. (2022). Complete hydatidiform mole in higher-order multiple pregnancies. Minerva Obstetrics and Gynecology, 74(3), 308-313.

https://doi.org/10.23736/S2724-606X.21.05031-4

Snell, B. (2009). Assessment and management of bleeding in the first trimester of pregnancy. Journal of midwifery & women's health, 54(6), 483-491.

https://doi.org/10.1016/j.jmwh.2009.08.007

Sotiriadis, A., Makrydimas, G., Papatheodorou, S., & Ioannidis, J.P. (2005). Expectant, medical, or surgical management of first-trimester miscarriage: A meta-analysis. Obstetrics & Gynecology, 105(5 Part 1), 1104-1113.

https://doi.org/10.1097/01.AOG.0000158857.44046.a4

Sucak, G. (2009). Antifosfolipid antikorlar ve antifosfolipid sendromu. Deneysel ve Klinik Tıp Dergisi, 14(4).

https://doi.org/10.5835/jecm.v14i4.798

Ungureanu, C.O., Stanculea, F.C., Iordache, N., Georgescu, T.F., Ginghina, O., Mihailov, R., . . . Georgescu, D.E. (2024). Ruptured recurrent interstitial ectopic pregnancy successfully managed by laparoscopy. Diagnostics, 14(5), 506.

https://doi.org/10.3390/diagnostics14050506

Van Mello, N., Mol, F., Verhoeve, H., Van Wely, M., Adriaanse, A., Boss, E., . . . Friederich, J. (2013). Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum hcg concentrations? A randomized comparison. Human Reproduction, 28(1), 60-67.

https://doi.org/10.1093/humrep/des373

Vannuccini, S., Clifton, V.L., Fraser, I.S., Taylor, H.S., Critchley, H., Giudice, L.C., & Petraglia, F. (2016). Infertility and reproductive disorders: Impact of hormonal and inflammatory mechanisms on pregnancy outcome. Human reproduction update, 22(1), 104-115.

https://doi.org/10.1093/humupd/dmv044

Wall, L.L., & Yemane, A. (2022). Infectious complications of abortion. Paper presented at the Open forum infectious diseases.

https://doi.org/10.1093/ofid/ofac553

Wojcicki, J., Wawrysiuk, S., Sochacki-Wojcicka, N., Podlinska, O., Pietrych, L., & Szpotanska-Sikorska, M. (2023). More than a hundred thousand respondents within 48 h: How the power of social media helped to understand pregnancy loss in poland–a retrospective population-based cohort study. European Journal of Obstetrics & Gynecology and Reproductive Biology, 289, 29-35.

https://doi.org/10.1016/j.ejogrb.2023.08.008

Zainuddin, N. (2025). Peptoniphilus asaccharolyticus septic abortion precipitating cerebral venous thrombosis. IIUM Medical Journal Malaysia, 24(02).

https://doi.org/10.31436/imjm.v24i02.2571

Zhang, J., Gilles, J.M., Barnhart, K., Creinin, M.D., Westhoff, C., & Frederick, M.M. (2005). A comparison of medical management with misoprostol and surgical management for early pregnancy failure. New England Journal of Medicine, 353(8), 761-769.

https://doi.org/10.1056/NEJMoa044064

Zhang, X., Fan, J., Chen, Y., Wang, J., Song, Z., Zhao, J., . . . Hu, Y. (2021). Cytogenetic analysis of the products of conception after spontaneous abortion in the first trimester. Cytogenetic and Genome Research, 161(3-4), 120-131.

https://doi.org/10.1159/000514088