AKDENİZ DİYETİ VE MENTAL İYİ OLUŞ ARASINDAKİ İLİŞKİ: GÜNCEL KANITLAR VE BİYOLOJİK MEKANİZMALAR

Alexatou, O., Sarafoglou, K., Vasilopoulos, G., et al. (2026). Mediterranean diet adherence is associated with lower prevalence of depression and anxiety in university students: A cross-sectional study in Greece. Diseases. https://doi.org/10.3390/diseases14010019

Ali, Q., Ma, S., Farooq, U., Niu, J., Li, F., Li, D., Wang, Z., Sun, H., Cui, Y., & Shi, Y. (2022). Pasture intake protects against commercial diet-induced lipopolysaccharide production facilitated by gut microbiota through activating intestinal alkaline phosphatase enzyme in meat geese. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1041070

Amini, Z., & HeidariFarsani, E. (2023). Investigating the effect of zinc supplementation on probability of relapse and mental health in patients with opioid use disorder undergoing methadone maintenance treatment. Substance Abuse Treatment Prevention and Policy, 18(1). https://doi.org/10.1186/s13011-023-00514-5

Andrés, C., Lastra, J. M. P. de la, Plou, F. J., & Pérez‐Lebeña, E. (2021). The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies. International Journal of Molecular Sciences, 22(9), 4642–4642. https://doi.org/10.3390/ijms22094642

Asensi, M. T., Napoletano, A., Sofi, F., & Dinu, M. (2023). Low-Grade Inflammation and Ultra-Processed Foods Consumption: A Review. Nutrients, 15(6), 1546–1546. https://doi.org/10.3390/nu15061546

Açık, M., Durmaz, S. E., Gümüş, A. B., & Açık, D. E. (2025). Uyku Düzeninden Kahvaltı Alışkanlıklarına: Biyolojik Ritim Bozukluklarının Mental Sağlığa Yansımaları. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 14(4), 1307–1320. https://doi.org/10.37989/gumussagbil.1817761

Barrera‐Chamorro, L., Fernández‐Prior, Á., Claro, C., Rio-Vazquez, J. L. D., Rivero‐Pino, F.,& Paz, S. M. la. (2024). Unveiling the neuroprotective impact of virgin olive oil ingestion via the microbiota–gut–brain axis. Food & Function, 16(1), 24–39. https://doi.org/10.1039/d4fo04560b

Bautista, J., Hidalgo‐Tinoco, C., Delgado, M. D., Viteri-Recalde, J., Guerra-Guerrero, A., & López‐Cortés, A. (2025). The gut–brain–circadian axis in anxiety and depression: a critical review. Frontiers in Psychiatry, 16. Frontiers Media. https://doi.org/10.3389/fpsyt.2025.1697200

Bayes, J., Schloss, J., & Sibbritt, D. (2023). The use of diet for preventing and treating depression in young men: current evidence and existing challenges. British Journal Of Nutrition, 131(2), 214–218. Cambridge University Press. https://doi.org/10.1017/s000711452300168x

Bertollo, A. G., Santos, C. F., Bagatini, M. D., & Ignácio, Z. M. (2025). Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression. Frontiers in Neuroscience, 19, 1541075–1541075. https://doi.org/10.3389/fnins.2025.1541075

Borrego-Ruiz, A., & Borrego, J. J. (2024). Human gut microbiome, diet, and mental disorders. International Microbiology. Springer Science+Business Media. https://doi.org/10.1007/s10123-024-00518-6

Chaudhary, P., Janmeda, P., Docea, A. O., Yeskaliyeva, B., Razis, A. F. A., Modu, B., Călina, D., & Sharifi‐Rad, J. (2023). Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases. Frontiers in Chemistry, 11, 1158198–1158198. Frontiers Media. https://doi.org/10.3389/fchem.2023.1158198

Choe, U. (2025). Role of dietary fiber and short-chain fatty acids in preventing neurodegenerative diseases through the gut-brain axis. Journal of Functional Foods, 129, 106870–106870. https://doi.org/10.1016/j.jff.2025.106870

Colletti, A., Pellizzato, M., & Cicero, A. F. G. (2023). The Possible Role of Probiotic Supplementation in Inflammation: A Narrative Review. Microorganisms, 11(9), 2160–2160. https://doi.org/10.3390/microorganisms11092160

Connell, E., Gall, G. L., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022). Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia. Molecular Neurodegeneration, 17(1). BioMed Central. https://doi.org/10.1186/s13024-022-00548-6

Correia, A. S., Cardoso, A., & Vale, N. (2023). Oxidative Stress in Depression: The Link with the Stress Response, Neuroinflammation, Serotonin, Neurogenesis and Synaptic Plasticity. Antioxidants, 12(2), 470–470. https://doi.org/10.3390/antiox12020470

Córdova-Jaya, V. R., & Toala-Parrales, J. M. (2026). Microbiota intestinal y trastorno del estado de ánimo: una revisión desde la nutrición. Revista Científica Zambos., 5(1), 203–213. https://doi.org/10.69484/rcz/v5/n1/161

Çetintaş, I., & Sut, C. (2023). Depresyonu Besin Öğeleri ile Önleyebilir veya Şiddetini Azaltabilir Miyiz? Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 8(3), 492–500. https://doi.org/10.51754/cusbed.1259315

Çin, N. N. A., Şeref, B., Özçelik, A. Ö., Atav, S., & Begdache, L. (2021). Validity and reliability of Turkish version of the Food–Mood Questionnaire for university students. Public Health Nutrition, 25(4), 841–849. https://doi.org/10.1017/s1368980021004377

Dal, N., & Bilici, S. (2024). An Overview of the Potential Role of Nutrition in Mental Disorders in the Light of Advances in Nutripsychiatry. Current Nutrition Reports, 13(2), 69–81. https://doi.org/10.1007/s13668-024-00520-4

Das, S., Banerjee, P., Jana, S., & Mondal, H. (2025). Unveiling the mechanistic nexus: how micronutrient enrichment shapes brain function, and cognitive health. Frontiers in Molecular Biosciences, 12. Frontiers Media. https://doi.org/10.3389/fmolb.2025.1623547

Dazıroğlu, M. E. Ç., & Akbulut, G. (2024). Akdeniz Diyet Bileşenlerinin Bilişsel Sağlık Üzerine Etkisi. Journal of Nutrition and Dietetics, 52(1), 117–122. https://doi.org/10.33076/2024.bdd.1818

Dimopoulou, M., Dimopoulou, A., & Gortzi, O. (2025). Dietary Patterns and Mental Health Across the Lifespan: A Systematic Review of Randomized Clinical Trials. Psychology International, 7(4), 87–87. https://doi.org/10.3390/psycholint7040087

Domínguez‐López, I., López‐Yerena, A., Vallverdú‐Queralt, A., Pallàs, M., Lamuela‐Raventós, R. M., & Pérez, M. (2024). From the gut to the brain: the long journey of phenolic compounds with neurocognitive effects. Nutrition Reviews, 83(2). https://doi.org/10.1093/nutrit/nuae034

Duan, T., Du, Y., Xing, C., Wang, H. Y., & Wang, R. (2022). Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity. Frontiers in Immunology, 13, 812774–812774. Frontiers Media. https://doi.org/10.3389/fimmu.2022.812774

Esposito, S., Gialluisi, A., Costanzo, S., Castelnuovo, A. D., Ruggiero, E., Curtis, A. D., Persichillo, M., Cerletti, C., Donati, M. B., Gaetano, G. de, Iacoviello, L., Bonaccio, M., & Study, on behalf of the I. for the M.-S. (2021). Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study. Nutrients, 13(5), 1701–1701. https://doi.org/10.3390/nu13051701

Fan, Y., Zhao, L., Deng, Z., Li, M., Huang, Z., Zhu, M., & Xu, W. (2022). Non-linear association between Mediterranean diet and depressive symptom in U.S. adults: A cross-sectional study. Frontiers in Psychiatry, 13. https://doi.org/10.3389/fpsyt.2022.936283

Farhan, M., & Faisal, M. (2024). The potential role of polyphenol supplementation in preventing and managing depression: A review of current research. Life, 14(10), 1342. https://doi.org/10.3390/life14101342

Ferri, A., Paes, L. T., Schneider, E., Clarke, G., & Cryan, J. F. (2026). From Fork to Feelings: How Foods Shape Mental Health via the Microbiota–Gut–Brain Axis. Annual Review of Food Science and Technology. https://doi.org/10.1146/annurev-food-053124-110137

Firdos, S., Amanullah, M., & Abid, N. (2025). Feeding the Mind: The Systematic Review on the Impact of Mediterranean Diet on Mental Well-being. Current Nutrition & Food Science, 22. https://doi.org/10.2174/0115734013399826251001113745

Firth, J., Marx, W., Dash, S., Carney, R., Teasdale, S. B., Solmi, M., ... & Berk, M. (2025). The impact of the Mediterranean diet on alleviating depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials. Psychological Medicine, 55(6), 1115–1128. https://doi.org/10.1017/S0033291724001234

Franzoni, F., Scarfò, G., Guidotti, S., Fusi, J., Асомов, М. И., & Pruneti, C. (2021). Oxidative Stress and Cognitive Decline: The Neuroprotective Role of Natural Antioxidants. Frontiers in Neuroscience, 15. Frontiers Media. https://doi.org/10.3389/fnins.2021.729757

Frausto, D. M., Forsyth, C. B., Keshavarzian, A., & Voigt, R. M. (2021). Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota. Frontiers in Neuroscience, 15. Frontiers Media. https://doi.org/10.3389/fnins.2021.736814

Fusco, W. G., Bernabeu, M., Cintoni, M., Porcari, S., Rinninella, E., Kaitsas, F., Lener, E., Mele, M. C., Gasbarrini, A., Collado, M. C., Cammarota, G., & Ianiro, G. (2023). Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota. Nutrients, 15(9), 2211–2211. https://doi.org/10.3390/nu15092211

Gain, C., Song, S., Angtuaco, T., Satta, S., & Kelesidis, T. (2023). The role of oxidative stress in the pathogenesis of infections with coronaviruses. Frontiers in Microbiology, 13. Frontiers Media. https://doi.org/10.3389/fmicb.2022.1111930

Grajek, M., Krupa-Kotara, K., Białek-Dratwa, A., Sobczyk, K., Grot, M., Kowalski, O., & Staśkiewicz‐Bartecka, W. (2022). Nutrition and mental health: A review of current knowledge about the impact of diet on mental health. Frontiers in Nutrition, 9. Frontiers Media. https://doi.org/10.3389/fnut.2022.943998

Günüç, S., &Şendemir, A. (2022). Beyin ve Bağırsak Mikrobiyotası Arasındaki İlişkinin Bilişsel Duygusal Davranışsal ve Fizyolojik Açıdan Değerlendirilmesi. Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry, 14(4), 446–459. https://doi.org/10.18863/pgy.1034963

Gümüş, E., & Yılmaz, M. (2025). Yetişkin bireylerin Akdeniz diyet yeterlilikleri, mental iyi oluşları ve fiziksel aktivite düzeyleri arasındaki ilişki. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 14(1), 45–56.

Han, X., Liu, Y., Wei, Y., Ma, L., Lim, S. Y., & Wang, Z. (2026). The mechanism of natural dietary polyphenols on inhibiting inflammation and modulating gut-brain axis: an effective way to prevent depression. Agricultural Products Processing and Storage, 2(1). https://doi.org/10.1007/s44462-025-00054-0

Hassamal, S. (2023). Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories. Frontiers in Psychiatry, 14. Frontiers Media. https://doi.org/10.3389/fpsyt.2023.1130989

Hays, K. E., Pfaffinger, J. M., & Ryznar, R. (2024). The interplay between gut microbiota, short-chain fatty acids, and implications for host health and disease. PubMed Central, 16(1), 2393270–2393270. https://doi.org/10.1080/19490976.2024.2393270

Jadiya, P., Garbincius, J. F., & Elrod, J. W. (2021). Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling. Acta Neuropathologica Communications, 9(1). Springer Science+Business Media. https://doi.org/10.1186/s40478-021-01224-4

Jameson, K. G., Kazmi, S. A., Ohara, T. E., Son, C., Yu, K. B., Mazdeyasnan, D., Leshan, E., Vuong, H. E., Paramo, J., Lopez-Romero, A., Long, Y., Schweizer, F. E., & Hsiao, E. Y. (2024). Select microbial metabolites in the small intestinal lumen regulate vagal activity via receptor-mediated signaling. eScholarship (California Digital Library), 28(2), 111699–111699. https://doi.org/10.1016/j.isci.2024.111699

Javanmehr, N., Saleki, K., Alijanizadeh, P., & Rezaei, N. (2022). Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases. Journal of Neuroinflammation, 19(1). BioMed Central. https://doi.org/10.1186/s12974-022-02637-1

Johansson, B., Andréll, P., Mannheimer, C., & Rönnbäck, L. (2022). Mental fatigue - possible explanations, diagnostic methods and possible treatments 119.

Kabthymer, R. H., Karimi, L., Livesay, K., et al. (2025). Effect of Mediterranean diet on mental health outcomes: A systematic review. Nutrition Research Reviews. https://doi.org/10.1017/S0954422425100243

Kasarełło, K., Cudnoch-Jędrzejewska, A., & Czarzasta, K. (2023). Communication of gut microbiota and brain via immune and neuroendocrine signaling. Frontiers in Microbiology, 14. Frontiers Media. https://doi.org/10.3389/fmicb.2023.1118529

Keskin, E. (2025). Bağırsak Mikrobiyotası ve Fekal Mikrobiyota Transplantasyonu: Klinik Uygulamalar ve Gelecek Perspektifleri. Arşiv Kaynak Tarama Dergisi, 34(1), 31–43. https://doi.org/10.17827/aktd.1589820

Kinashi, Y., & Hase, K. (2021). Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity. Frontiers in Immunology, 12. Frontiers Media. https://doi.org/10.3389/fimmu.2021.673708

Kris‐Etherton, P. M., Petersen, K., Hibbeln, J. R., Hurley, D. L., Kolick, V., Peoples, S., Rodriguez, N. R., & Woodward‐Lopez, G. (2020). Nutrition and behavioral health disorders: depression and anxiety. Nutrition Reviews, 79(3), 247–260. Oxford University Press. https://doi.org/10.1093/nutrit/nuaa025

Kurtbeyoğlu, E., Akduman, G., & Güneş, F. E. (2021). A Different View of Nutrition in Depression: The Importance of Nutrients on Physiopathological Pathways. Turkiye Klinikleri Journal of Health Sciences, 6(2), 320–328. https://doi.org/10.5336/healthsci.2020-76016

Lai, Y., Liu, C., Yang, Y., Hsiao, Y.-C., Ru, H., & Lü, K. (2021). High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26209-8

Leyrolle, Q., Prado-Perez, L., & Layé, S. (2023). The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain. Frontiers in Nutrition, 10. Frontiers Media. https://doi.org/10.3389/fnut.2023.1155533

Lin, K., Li, Y., Toit, E. D., Wendt, L., & Sun, J. (2021). Effects of Polyphenol Supplementations on Improving Depression, Anxiety, and Quality of Life in Patients With Depression. Frontiers in Psychiatry, 12, 765485–765485. https://doi.org/10.3389/fpsyt.2021.765485

Lin, L.-Y., George, J., & Liu, G. (2025). Biomarker Quantification of Gut Dysbiosis-Derived Inflammation: A Review. Journal of Inflammation Research, 14551–14567. https://doi.org/10.2147/jir.s539155

Liu, H., Zhang, X., Shi, P., Yuan, J., Jia, Q., Pi, C., Chen, T., Xiong, L., Chen, J., Tang, J., Yue, R., Liu, Z., Shen, H., Zuo, Y., Wei, Y., & Zhao, L. (2023). α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect. Journal of Neuroinflammation, 20(1). BioMed Central. https://doi.org/10.1186/s12974-023-02768-z

Loh, J. S., Mak, W. Q., Tan, L., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024). Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases. Signal Transduction and Targeted Therapy, 9(1). Springer Nature. https://doi.org/10.1038/s41392-024-01743-1

Lountzis, G. (2024). Self-care practices in decision-making: How nutrition and habits may affect decision in business. European Journal of Environment and Public Health, 8(1). https://doi.org/10.29333/ejeph/14128

Lourida, I., Hsu, Y. ‑H., & Llewellyn, D. J. (2025). Effect of Mediterranean diet on mental health outcomes: A systematic review. Nutrition Research Reviews, 38(2), 123–145. https://doi.org/10.1017/S0954422425000112

Lukić, I., Ivković, S., Mitić, M., & Adžić, M. (2022). Tryptophan metabolites in depression: Modulation by gut microbiota. Frontiers in Behavioral Neuroscience, 16. Frontiers Media. https://doi.org/10.3389/fnbeh.2022.987697

Madison, A. A., & Kiecolt‐Glaser, J. K. (2019). Stress, depression, diet, and the gut microbiota: human–bacteria interactions at the core of psychoneuroimmunology and nutrition. Current Opinion in Behavioral Sciences, 28, 105–110. https://doi.org/10.1016/j.cobeha.2019.01.011

Magzal, F., Turroni, S., Fabbrini, M., Barone, M., Schorr, A. V., Ofran, A., & Tamir, S. (2023). A personalized diet intervention improves depression symptoms and changes microbiota and metabolite profiles among community-dwelling older adults. Frontiers in Nutrition, 10. https://doi.org/10.3389/fnut.2023.1234549

Mahmoud, M. M., Mansour, S. Z., Helal, H., & Ahmed, E. S. A. (2022). Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity by activation of Nrf2 and suppression of inflammatory mediators in rats. Environmental Science and Pollution Research, 29(49), 75086–75100. https://doi.org/10.1007/s11356-022-21126-9

Mamun, A. A., Shao, C., Geng, P., Wang, S., & Xiao, J. (2024). Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far? International Journal of Biological Sciences, 20(4), 1332–1355. https://doi.org/10.7150/ijbs.90982

Merlo, G., Bachtel, G., & Sugden, S. G. (2024). Gut microbiota, nutrition, and mental health. Frontiers in Nutrition, 11. https://doi.org/10.3389/fnut.2024.1337889

Miri, S., Yeo, J., Abubaker, S., & Hammami, R. (2023). Neuromicrobiology, an emerging neurometabolic facet of the gut microbiome? Frontiers in Microbiology, 14. Frontiers Media. https://doi.org/10.3389/fmicb.2023.1098412

Misrani, A., Tabassum, S., & Yang, L. (2021). Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease. Frontiers in Aging Neuroscience, 13. Frontiers Media. https://doi.org/10.3389/fnagi.2021.617588

Mitchell, E. S., Conus, N., & Kaput, J. (2014). B vitamin polymorphisms and behavior: Evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neuroscience & Biobehavioral Reviews, 47, 307–320. https://doi.org/10.1016/j.neubiorev.2014.08.006

Mohammad, S., & Thiemermann, C. (2021). Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions. Frontiers in Immunology, 11. Frontiers Media. https://doi.org/10.3389/fimmu.2020.594150

Muro, P. D., Zhang, L., Li, S., Zhao, Z., Jin, T., Mao, F., & Mao, Z. (2024). The emerging role of oxidative stress in inflammatory bowel disease. Frontiers in Endocrinology, 15. Frontiers Media. https://doi.org/10.3389/fendo.2024.1390351

Nabeh, O. A., Amr, A., Faoosa, A. M., Esmat, E., Osama, A., Khedr, A. S., Amin, B., Saud, A., & Elmorsy, S. A. (2024). Emerging Perspectives on the Impact of Diabetes Mellitus and Anti-Diabetic Drugs on Premenstrual Syndrome. A Narrative Review. Diabetes Therapy, 15(6), 1279–1299. Adis, Springer Healthcare. https://doi.org/10.1007/s13300-024-01585-8

Otağ, M. R. (2023). Determination of Bioactive Properties and Antimicrobial Activities of Extracts of Black Tea and Black Tea Waste Samples Obtained at Different Solvent Concentrations. Journal of Anatolian Environmental and Animal Sciences, 8(1), 80–87. https://doi.org/10.35229/jaes.1226432

Ömür, S., & Kalkan, İ. (2023). Fermente Besinlerin Beyin-Bağırsak Ekseni ve Psikiyatrik Bozukluklara Etkisi. DergiPark (Istanbul University), 8(3), 1087–1093. https://doi.org/10.61399/ikcusbfd.1246338

Parletta, N., Zarnowiecki, D., Cho, J., Wilson, A., Bogomolova, S., Villani, A., Itsiopoulos, C., Niyonsenga, T., Blunden, S., Meyer, B. J., Segal, L., & O’Dea, K. (2017). A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED). Nutrients, 9(12), 1228. https://doi.org/10.3390/nu9121228

Patil, S., & Sharif, M. (2025). The Gut-Brain Axis and Mental Health: How Diet Shapes Our Cognitive and Emotional Well-Being. Cureus, 17(7). https://doi.org/10.7759/cureus.88420

Pereira, L. M., Pinto, E. R., Brasil, B. G., & Silveira, D. M. (2023). Dieta mediterrânea e seu impacto na prevenção do transtorno depressivo. Research Society and Development, 12(14). https://doi.org/10.33448/rsd-v12i14.43379

Perrone, P., & D’Angelo, S. (2025). Gut Microbiota Modulation Through Mediterranean Diet Foods: Implications for Human Health. Nutrients, 17(6), 948–948. https://doi.org/10.3390/nu17060948

Plachá, D., & Jampílek, J. (2021). Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems. Pharmaceutics, 13(1), 64–64. Multidisciplinary Digital Publishing Institute. https://doi.org/10.3390/pharmaceutics13010064

Poff, A. M., Moss, S., Soliven, M. A., & D’Agostino, D. P. (2021). Ketone Supplementation: Meeting the Needs of the Brain in an Energy Crisis. Frontiers in Nutrition, 8. Frontiers Media. https://doi.org/10.3389/fnut.2021.783659

Portugal‐Nunes, C., Nunes, F. M., Fraga, I., Saraiva, C., & Gonçalves, C. (2021). Assessment of the Methodology That Is Used to Determine the Nutritional Sustainability of the Mediterranean Diet—A Scoping Review. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.772133

Prinz, M., Masuda, T., Wheeler, M. A., & Quintana, F. J. (2021). Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation. Annual Review of Immunology, 39(1), 251–277. https://doi.org/10.1146/annurev-immunol-093019-110159

Pérez-Barrientos, J. F. (2022). Implications of chronic stress and inflammation in major depressive disorder. Medicina Universitaria, 24(3). https://doi.org/10.24875/rmu.22000027

Pérez-Reytor, D., Puebla, C., Karahanian, E., & García, K. (2021). Use of Short-Chain Fatty Acids for the Recovery of the Intestinal Epithelial Barrier Affected by Bacterial Toxins. Frontiers in Physiology, 12. Frontiers Media. https://doi.org/10.3389/fphys.2021.650313

Rudrapal, M., Khairnar, S. J., Khan, J., Dukhyil, A. B., Ansari, M. A., Alomary, M. N., Alshabrmi, F. M., Palai, S., Deb, P. K., & Devi, R. (2022). Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action. Frontiers in Pharmacology, 13, 806470–806470. Frontiers Media. https://doi.org/10.3389/fphar.2022.806470

Róg, J., Pawlikowska, P., Futyma-Jędrzejewska, M., Wróbel-Knybel, P., Maciejewski, R., Kulczycka, K., & Karakula-Juchnowicz, H. (2025). Polyphenol Consumption and Its Association with Physical and Mental Health in Adults with Major Depressive Disorder. Nutrients, 18(1), 47–47. https://doi.org/10.3390/nu18010047

Sánchez‐Villegas, A., Henríquez, P., Bes‐Rastrollo, M., & Doreste, J. (2006). Mediterranean diet and depression. Public Health Nutrition, 9, 1104–1109. https://doi.org/10.1017/s1368980007668578

Serrano, M., Saumell-Esnaola, M., Ocerin, G., Caño, G. G. del, Puente, N., Sallés, J., Fonseca, F. R. de, Rodrı́guez-Arias, M., Gerrikagoitia, I., & Grandes, P. (2024). Impact of Omega-3 on Endocannabinoid System Expression and Function, Enhancing Cognition and Behavior in Male Mice. Nutrients, 16(24), 4344–4344. https://doi.org/10.3390/nu16244344

Shiraseb, F., Hosseininasab, D., Noori, S., Ebrahimi, S., Asjodi, F., Ghaffarian-Ensaf, R., Carnauba, R. A., & Mirzaei, K. (2023). Inflammatory biomarkers in overweight and obese Iranian women are associated with polyphenol intake. Journal of Health Population and Nutrition, 42(1). https://doi.org/10.1186/s41043-023-00376-4

Sofi, F., Abbate, R., Gensini, G. F., & Casini, A. (2010). Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. American Journal of Clinical Nutrition, 92(5), 1189–1196. https://doi.org/10.3945/ajcn.2010.29673

Song, J., Fu, A., Wang, C., & Rajabi, S. (2025). A comprehensive review on the impact of polyphenol supplementation and exercise on depression and brain function parameters. Behavioral and Brain Functions, 21(1). BioMed Central. https://doi.org/10.1186/s12993-025-00273-2

Steullet, P. (2024). Editorial for the Special Issue “Oxidative Stress, Inflammation and Antioxidant Defense System in Psychiatric Disorders” in Antioxidants (2022–2023). Antioxidants, 13(11), 1307–1307. https://doi.org/10.3390/antiox13111307

Sălcudean, A., Bodo, C.-R., Popovici, R. A., Lica, M. M., Păcurar, M., Crăciun, R.-E., Crișan, A.-I., Enatescu, V. R., Marinescu, I., Cîmpian, D.-M., Nan, A. G., Sasu, A.-B., Anculia, R.-C., & Strete, E. G. (2025). Neuroinflammation—A Crucial Factor in the Pathophysiology of Depression—A Comprehensive Review. Biomolecules, 15(4), 502–502. https://doi.org/10.3390/biom15040502

Tavakoly, R., Moosburner, A., Anheyer, D., & Cramer, H. (2025). Effect of Different Dietary Patterns on Patients with Depressive Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 17(3), 563–563. https://doi.org/10.3390/nu17030563

Tofani, G., Leigh, S., Gheorghe, C. E., Bastiaanssen, T. F. S., Wilmes, L., Sen, P., Clarke, G., & Cryan, J. F. (2024). Gut microbiota regulates stress responsivity via the circadian system. Cell Metabolism, 37(1), 138. https://doi.org/10.1016/j.cmet.2024.10.003

Tokpunar, M. (2022). The Relationship between Sustainable Dietary Patterns and Depression: A Review. DergiPark. Istanbul University. https://dergipark.org.tr/tr/pub/jgehes/issue/86379/1196191

Tokpunar, M. (2024). Sürdürülebilir Diyet Modellerinin Depresyon ile İlişkisi: Derleme. Journal of General Health Sciences (JGEHES) Necmettin Erbakan University. https://doi.org/10.51123/jgehes.2024.134

Tommaso, N. D., Gasbarrini, A., & Ponziani, F. R. (2021). Intestinal Barrier in Human Health and Disease. International Journal of Environmental Research and Public Health, 18(23), 12836–12836. https://doi.org/10.3390/ijerph182312836

Torre, D. L., Verbeke, K., & Dalile, B. (2021). Dietary fibre and the gut–brain axis: microbiota-dependent and independent mechanisms of action. Gut Microbiome, 2. Cambridge University Press. https://doi.org/10.1017/gmb.2021.3

Trombetti, M., & Hsu, C.-Y. (2018). Effects of polyphenols in a Mediterranean diet on symptoms of depression: A systematic review. Antioxidants, 7(6), 83

Ünal, G., & Özenoğlu, A. (2024). Association of Mediterranean diet with sleep quality, depression, anxiety, stress, and body mass index in university students: A cross-sectional study. Nutrition and Health, 31(2), 659–666. https://doi.org/10.1177/02601060231207666

Vanuytsel, T., Tack, J., & Farré, R. (2021). The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation. Frontiers in Nutrition, 8. Frontiers Media. https://doi.org/10.3389/fnut.2021.717925

Vidović, B. (2023). Dietary antioxidants and health effects: What are their optimal intakes? Arhiv Za Farmaciju, 73(4), 278–291. https://doi.org/10.5937/arhfarm73-45552

Vincenzo, F. D., Gaudio, A. D., Petito, V., Lopetuso, L. R., & Scaldaferri, F. (2023). Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review. Internal and Emergency Medicine, 19(2), 275–293. Springer Science+Business Media. https://doi.org/10.1007/s11739-023-03374-w

Wang, L., Wang, Z., Lan, Y., Tuo, Y., Ma, S., & Liu, X. (2023). Inulin Attenuates Blood–Brain Barrier Permeability and Alleviates Behavioral Disorders by Modulating the TLR4/MyD88/NF-κB Pathway in Mice with Chronic Stress. Journal of Agricultural and Food Chemistry, 71(36), 13325–13337. https://doi.org/10.1021/acs.jafc.3c03568

Wang, X., Yu, J., & Zhang, X. (2022). Dietary polyphenols as prospective natural-compound depression treatment from the perspective of intestinal microbiota regulation. Molecules, 27(21), 7637. https://doi.org/10.3390/molecules27217637

Warren, A., & Frame, L. A. (2025). Restoring a Healthy Relationship with Food by Decoupling Stress and Eating: A Translational Review of Nutrition and Mental Health. Nutrients, 17(15), 2466–2466. https://doi.org/10.3390/nu17152466

Wu, A., & Zhang, J. (2023). Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis. Journal of Neuroinflammation, 20(1). BioMed Central. https://doi.org/10.1186/s12974-023-02964-x

Yadav, E., Yadav, P., Khan, M. M. U., Singh, H., & Verma, A. (2022). Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction. Frontiers in Pharmacology, 13. Frontiers Media. https://doi.org/10.3389/fphar.2022.922232

Yan, M., Man, S., Sun, B., Ma, L., Guo, L., Huang, L., & Gao, W. (2023). Gut liver brain axis in diseases: the implications for therapeutic interventions. Signal Transduction and Targeted Therapy, 8(1). Springer Nature. https://doi.org/10.1038/s41392-023-01673-4

Yao, Z., Li, H., Liao, P., Chen, L., Pan, Y., Zheng, Y., Zhang, C., Liu, D., Zheng, M., & Gao, J. (2024). Mitochondrial dysfunction: mechanisms and advances in therapy. Signal Transduction and Targeted Therapy, 9(1). Springer Nature. https://doi.org/10.1038/s41392-024-01839-8

Yu, X., Pu, H., & Voss, M. A. (2024). Overview of anti-inflammatory diets and their promising effects on non-communicable diseases. British Journal Of Nutrition, 132(7), 898–918. Cambridge University Press. https://doi.org/10.1017/s0007114524001405

Yılmaz, İ., & Üner, M. H. (2021). Oksidatif Stres ve Antioksidanların İş Sağlığına Etkileri. Karaelmas İş Sağlığı ve Güvenliği Dergisi, 5(1), 79–87. https://doi.org/10.33720/kisgd.772993

Zhang, K., Ma, Y., Luo, Y., Song, Y., Xiong, G., Ma, Y., Sun, X., & Kan, C. (2023). Metabolic diseases and healthy aging: identifying environmental and behavioral risk factors and promoting public health. Frontiers in Public Health, 11. Frontiers Media. https://doi.org/10.3389/fpubh.2023.1253506

Zhang, R., Ruting, W., Hongxi, W., Zhenjin, H., Jiale, L., Zhang, R., Jiang, F., & Yuanbo, S. (2025). Gut microbiota as a novel target for treating anxiety and depression: from mechanisms to multimodal interventions. Frontiers in Microbiology, 16. https://doi.org/10.3389/fmicb.2025.1664800

Zhang, R., Zhang, B., Shen, C., Sahakian, B. J., Li, Z., Zhang, W., Zhao, Y., Li, Y., Feng, J., & Cheng, W. (2024). Associations of dietary patterns with brain health from behavioral, neuroimaging, biochemical and genetic analyses. Nature Mental Health, 2(5), 535–552. https://doi.org/10.1038/s44220-024-00226-0

Zhou, L., Xiong, J., Chai, Y.-Q., Huang, L., Tang, Z., Zhang, X., Liu, B., & Zhang, J. (2022). Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system. Frontiers in Psychiatry, 13. Frontiers Media. https://doi.org/10.3389/fpsyt.2022.933704

Zhu, X., Hu, Y., Dai, Z., Li, X., & Zhang, J. (2024). Associations between trans fatty acids and systemic immune-inflammation index: a cross-sectional study. Lipids in Health and Disease, 23(1). https://doi.org/10.1186/s12944-024-02109-w

Zhu, X., Li, B., Lou, P., Dai, T., Chen, Y., Zhuge, A., Yuan, Y., & Li, L. (2021). The Relationship Between the Gut Microbiome and Neurodegenerative Diseases. Neuroscience Bulletin, 37(10), 1510–1522. Springer Science+Business Media. https://doi.org/10.1007/s12264-021-00730-8

Zinkow, A., Grodzicki, W., Czerwińska, M., & Dziendzikowska, K. (2024). Molecular Mechanisms Linking Omega-3 Fatty Acids and the Gut–Brain Axis. Molecules, 30(1), 71–71. https://doi.org/10.3390/molecules30010071

Zonneveld, S. M. van, Oever, E. J. van den, Haarman, B., Grandjean, E. L., Nuninga, J. O., Rest, O. van de, & Sommer, I. E. (2024). An Anti-Inflammatory Diet and Its Potential Benefit for Individuals with Mental Disorders and Neurodegenerative Diseases—A Narrative Review. Nutrients, 16(16), 2646–2646. https://doi.org/10.3390/nu16162646