İNFERTİLİTEDE GÜNCEL YAKLAŞIMLAR VE PSİKOSOSYAL SÜREÇLER
Özet
İnfertilite, düzenli ve korunmaz cinsel üremesine rağmen 12 ay veya daha uzun bir süre içerisinde gebeliğin elde edilememesi ile değişmesi, kadın ve erkek üreme sisteminin uzamasıen önemli bir üreme sağlık sorunudur. Günümüzdeki doğum planının ileri yaşlara ertelenmesi, yaşam tarzındaki değişiklikler, kronik hastalık ve patojenler gibi birçok faktör infertilitenin uzatılmasını artırmaktadır. Dünya Sağlık Örgütü'nün (DSÖ) güncel sistemlerine göre, yetişkinlerin yaklaşık altıda biri yaşamlarının herhangi bir dönemde kısırlık deneyimi yaşamakta; bu durum infertilitenin bireysel bir sağlık sorununun küresel çapta ele alınması gereken önemli bir halk sağlığı sorunu olduğunu göstermektedir (WHO, 2023).
İnfertilite, biyolojik problemlerin yanı sıra psikolojik, sosyal, ilişkisel ve ekonomik yaşamlarını değiştirebilecek çok boyutlu bir sağlık sorunudur. Tanı ve tedavi sürecinin sonuçları, tekrarlayan ve sonuçsuz sonuç veren tedavi tedavileri, oluşturulan ekonomik yük ve çocuk sahibi olmaya ilişkin toplumsal beklentiler bireyler ve çiftler üzerinde önemli bir psikososyal yük oluşturulabilmektedir. Bu süreçte stres, anksiyete ve depresif oluşumlar, benlik ayrılıklarında azalma, sosyal izolasyon, çift unsurlarda zorluklar ve yaşam kalitesinde bozulma görülebilmektedir. Bu nedenle kısırlık bakımının yalnızca tanı ve tedavi uygulamalarıyla sınırlandırılması; ve çiftlerin psikososyal hizmetlerinin de değerlendirilerek bütüncül ve bireysel odaklı bakımın benimsenmesi gerekmektedir (Gameiro ve ark., 2015).
Son yıllarda yardımcı üreme tekniklerindeki (YÜT) gelişmeler, genetik yönetim yöntemleri, kablosuz yapay destekli embriyo değerlendirme sistemleri ve kişiselleştirilmiş tedavi yöntemleri infertilitenin tanı ve tedavisinde önemli ilerlemeler sağlanmıştır. Bu, bireysel klinik özelliklerin ve tedavi yanıtlarının alındığı, daha hedeflenmiş tedavilerin geliştirilmesine olanak sağlamaktadır. Bununla birlikte güncel infertilite tedavisinin başarısının yalnızca teknolojik ve tıbbi gelişmelere dayanmakta olduğu; hasta merkezli bakım, etkili iletişim, ortak karar verme ve psikososyal desteğin tedavi hizmetlerinin entegrasyon de sistemleri (ASRM, 2024; Gameiro ve ark., 2015).
Bu bölümde kısırlığın güncel tanı ve tedavi tedavileri ile YÜT'deki gelişmeler özetlenmekte; İnfertilite bireyleri ve çiftler üzerindeki psikososyal etkiler, başlangıç değişimi ve sağlık profesyonellerinin, özellikle ebe ve resmilerin, bütüncül bakım kapsamındaki rolleri güncel bilgiler kapsamında ele alınmaktadır.
Anahtar Kelimeler: İnfertilite, Yardımcı üreme teknikleri, Fertilite tedavisi, psikososyal destek, kadın sağlığı, üreme sağlığı
Konu Alanı: Tıp -> Tıp (diğer) -> Kadın Hastalıkları ve Doğum
Agarwal, A., Baskaran, S., Parekh, N., Cho, C. L., Henkel, R., Vij, S., Arafa, M., Panner Selvam, M. K., ve Shah, R. (2021a). Male infertility. The Lancet, 397(10271), 319–333. https://doi.org/10.1016/S0140-6736(20)32667-2
Agarwal, A., Majzoub, A., Baskaran, S., Panner Selvam, M. K., Cho, C. L., Henkel, R., Finelli, R., ve Saleh, R. (2021b). Sperm DNA fragmentation: A new guideline for clinicians. World Journal of Men’s Health, 39(1), 1–15. https://doi.org/10.5534/wjmh.200128
AUA/ASRM (2024). American Urological Association (AUA), ve American Society for Reproductive Medicine (ASRM). Diagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline (2020; Amended 2024). American Urological Association.
Anderson, R. A., Amant, F., Braat, D., D’Angelo, A., Chuva de Sousa Lopes, S. M., Demeestere, I., Dwek, S., Frith, L., Lambertini, M., Maslin, C., Mourits, M., Nogueira, D., Rodriguez-Wallberg, K., ve Vermeulen, N. (2020). ESHRE guideline: Female fertility preservation. Human Reproduction Open, 2020(4), hoaa052. https://doi.org/10.1093/hropen/hoaa052
ASRM-Practice Committee of the American Society for Reproductive Medicine. (2017). Removal of myomas in asymptomatic patients to improve fertility and/or reduce miscarriage rate: A guideline. Fertility and Sterility, 108(3), 416–425. Retrieved July 29, 2026. https://doi.org/10.1016/j.fertnstert.2017.06.034
ASRM-Practice Committee of the American Society for Reproductive Medicine. (2020). Evidence-based treatments for couples with unexplained infertility: A guideline. Fertility and Sterility, 113(2), 305–322. https://doi.org/10.1016/j.fertnstert.2019.10.014
ASRM-Practice Committee of the American Society for Reproductive Medicine. (2021a). Fertility evaluation of infertile women: A committee opinion. Fertility and Sterility, 116(5), 1255–1265. https://doi.org/10.1016/j.fertnstert.2021.08.038
ASRM-Practice Committee of the American Society for Reproductive Medicine. (2021b). Role of tubal surgery in the era of assisted reproductive technology: A committee opinion. Fertility and Sterility, 115(5), 1143–1150. https://doi.org/10.1016/j.fertnstert.2021.01.051
ASRM-Practice Committee of the American Society for Reproductive Medicine. (2023). Definition of infertility: A committee opinion. Fertility and Sterility, 120(6), 1170. https://doi.org/10.1016/j.fertnstert.2023.10.001
ASRM-Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology. (2024). The use of preimplantation genetic testing for aneuploidy: A committee opinion. Fertility and Sterility, 122(3), 421–434. https://doi.org/10.1016/j.fertnstert.2024.04.013
Becker, C. M., Bokor, A., Heikinheimo, O., et al. (2022). ESHRE guideline: Endometriosis. Human Reproduction Open, 2022(2), hoac009. https://doi.org/10.1093/hropen/hoac009
Bundhun, P. K., Janoo, G., Bhurtu, A., Teeluck, A. R., Soogund, M. Z. S., Pursun, M., ve Huang, F. (2019). Tobacco smoking and semen quality in infertile males: A systematic review and meta-analysis. BMC Public Health, 19, 36. https://doi.org/10.1186/s12889-018-6319-3
Cakmak, H., & Taylor, H. S. (2011). Implantation failure: Molecular mechanisms and clinical treatment. Human Reproduction Update, 17(2), 242–253. https://doi.org/10.1093/humupd/dmq037
Capmas, P., Suarthana, E., & Tulandi, T. (2021). Management of hydrosalpinx in the era of assisted reproductive technology: A systematic review and meta-analysis. Journal of Minimally Invasive Gynecology, 28(3), 418–441. https://doi.org/10.1016/j.jmig.2020.08.017
Cobo, A., García-Velasco, J. A., Coello, A., Domingo, J., Pellicer, A., ve Remohí, J. (2020). Oocyte vitrification as an effective option for elective fertility preservation. Fertility and Sterility, 113(4), 703–709. https://doi.org/10.1016/j.fertnstert.2019.12.020
Craig, J. R., Jenkins, T. G., Carrell, D. T., ve Hotaling, J. M. (2017). Obesity, male infertility, and the sperm epigenome. Fertility and Sterility, 107(4), 848–859. https://doi.org/10.1016/j.fertnstert.2017.02.115
Dancet, E. A. F., Nelen, W. L. D. M., Sermeus, W., De Leeuw, L., Kremer, J. A. M., ve D’Hooghe, T. M. (2010). The patients’ perspective on fertility care: A systematic review. Human Reproduction Update, 16(5), 467–487. https://doi.org/10.1093/humupd/dmq004
ESHRE, ASRM, CREWHIRL and IMS Guideline Group on POI; Panay N, Anderson RA, Bennie A, Cedars M, Davies M, Ee C, Gravholt CH, Kalantaridou S, Kallen A, Kim KQ, Misrahi M, Mousa A, Nappi RE, Rocca WA, Ruan X, Teede H, Vermeulen N, Vogt E, Vincent AJ. Evidence-based guideline: premature ovarian insufficiency†‡. Climacteric. 2024 Dec;27(6):510-520. https://doi.org/10.1080/13697137.2024.2423213
Finelli, R., Leisegang, K., Kandil, H., & Agarwal, A. (2021). Oxidative stress: a comprehensive review of biochemical, molecular, and genetic aspects in the pathogenesis and management of varicocele. The World Journal of Men's Health, 40(1), 87. https://doi.org/10.5534/wjmh.210153
França, M.M., ve Mendonca, B.B. (2019). Genetics of Primary Ovarian Insufficiency in the Next-Generation Sequencing Era. J Endocr Soc. 2019 Feb 19;4(2):bvz037. https://doi.org/10.1210/jendso/bvz037
Gameiro, S., Boivin, J., Dancet, E. A. F., de Klerk, C., Emery, M., Lewis-Jones, C., Thorn, P., Van den Broeck, U., ve Verhaak, C. M. (2015). ESHRE guideline: Routine psychosocial care in infertility and medically assisted reproduction—A guide for fertility staff. Human Reproduction, 30(11), 2476–2485. https://doi.org/10.1093/humrep/dev177
Gaskins, A. J., ve Chavarro, J. E. (2021). Diet and fertility: A review. American Journal of Obstetrics and Gynecology, 224(4), 373–383. https://doi.org/10.1016/j.ajog.2020.11.066
Güner Emül, T., ve Avşar, B. (2021). İnfertilite tedavisinde sosyal destek ve hemşirenin rolü. Journal of Academic Research in Nursing, 7(2), 94–98. https://doi.org/10.55646/jaren.2021.97658
Gordon, C. M., Ackerman, K. E., Berga, S. L., Kaplan, J. R., Mastorakos, G., Misra, M., Murad, M. H., Santoro, N. F., & Warren, M. P. (2017). Functional hypothalamic amenorrhea: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 102(5), 1413–1439. https://doi.org/10.1210/jc.2017-00131
Gleicher, N., Kushnir, V. A., & Barad, D. H. (2018). Unexplained infertility. The Lancet, 392(10157), 1516–1517. https://doi.org/10.1016/S0140-6736(18)31890-7
Hanassab, S., Abbara, A., Yeung, A. C., Voliotis, M., Tsaneva-Atanasova, K., Kelsey, T. W., Trew, G. H., ve Nelson, S. M. (2024). The prospect of artificial intelligence to personalize assisted reproductive technology. npj Digital Medicine, 7, Article 52. https://doi.org/10.1038/s41746-024-01006-x
Howells, P., Vigneswaran, K., Sarris, I., Melo, P., Bhandari, H., & Subramanian, V. (2026). Management of endometrial polyps in fertility: British Fertility Society policy and practice guideline. Human Fertility, 29(1), 2633925. https://doi.org/10.1080/14647273.2026.2633925
Inhorn, M. C., ve Patrizio, P. (2015). Infertility around the globe: New thinking on gender, reproductive technologies and global movements in the 21st century. Human Reproduction Update, 21(4), 411–426. https://doi.org/10.1093/humupd/dmv016
Karayiannis, D., Kontogianni, M. D., Mendorou, C., Douka, L., Mastrominas, M., ve Yiannakouris, N. (2017). Association between adherence to the Mediterranean diet and semen quality parameters in male partners of couples attempting fertility. Human Reproduction, 32(1), 215–222. https://doi.org/10.1093/humrep/dew288
Khalafalla, K., El Ansari, W., Sengupta, P., Majzoub, A., Elbardisi, H., Canguven, O., El-Ansari, K., ve Arafa, M. (2023). Are sexually transmitted infections associated with male infertility? A systematic review and in-depth evaluation of the evidence and mechanisms of action of 11 pathogens. Arab Journal of Urology, 21(4), 216–232. https://doi.org/10.1080/2090598X.2023.2218566
Krausz, C., ve Riera-Escamilla, A. (2018). Genetics of male infertility. Nature Reviews Urology, 15, 369–384. https://doi.org/10.1038/s41585-018-0003-3
La Vignera, S., & Vita, R. (2018). Thyroid dysfunction and semen quality. International Journal of Immunopathology and Pharmacology, 32, 2058738418775241. https://doi.org/10.1177/2058738418775241
Lambalk, C. B. (2022). Delayed childbearing and medically assisted reproduction. Human Reproduction, 37(5), e1. https://doi.org/10.1093/humrep/deac037
Lin, K. B., ve Chen, C. H. (2025). Artificial intelligence and assisted reproductive technology: A comprehensive systematic review. Taiwanese Journal of Obstetrics and Gynecology, 64(1), 11–26. https://doi.org/10.1016/j.tjog.2024.10.001
Luk, B. H. K., ve Loke, A. Y. (2015). The impact of infertility on the psychological well-being, marital relationships, sexual relationships, and quality of life of couples: A systematic review. Journal of Sex ve Marital Therapy, 41(6), 610–625. https://doi.org/10.1080/0092623X.2014.958789
Mascarenhas, M. N., Flaxman, S. R., Boerma, T., Vanderpoel, S., ve Stevens, G. A. (2012). National, regional, and global trends in infertility prevalence since 1990: A systematic analysis of 277 health surveys. PLoS Medicine, 9(12), e1001356. https://doi.org/10.1371/journal.pmed.1001356
Oduwole, O. O., Peltoketo, H., ve Huhtaniemi, I. T. (2018). Role of follicle-stimulating hormone in spermatogenesis. Frontiers in Endocrinology, 9, 763. https://doi.org/10.3389/fendo.2018.00763
Potabattula, R., Dittrich, M., Schorsch, M., Hahn, T., Haaf, T, ve El Hajj, N. (2019). Male obesity effects on sperm and next-generation cord blood DNA methylation. PLoS ONE, 14(6), e0218615. https://doi.org/10.1371/journal.pone.0218615
Raperport, C., Desai, J., Qureshi, D., Rustin, E., Balaji, A., Chronopoulou, E., Homburg, R., Khan, K. S., ve Bhide, P. (2024). The definition of unexplained infertility: A systematic review. BJOG: An International Journal of Obstetrics ve Gynaecology, 131(7), 880–897. https://doi.org/10.1111/1471-0528.17697
Ricci, E., Al Beitawi, S., Cipriani, S., Candiani, M., Chiaffarino, F., Viganò, P., Noli, S., ve Parazzini, F. (2017). Semen quality and alcohol intake: A systematic review and meta-analysis. Reproductive BioMedicine Online, 34(1), 38–47. https://doi.org/10.1016/j.rbmo.2016.09.012
Ring, J. D., Lwin, A. A., ve Köhler, T. S. (2016). Current medical management of endocrine-related male infertility. Asian Journal of Andrology, 18(3), 357–363. https://doi.org/10.4103/1008-682X.179252
Rivero, M.J., Kulkarni, N., Thirumavalavan, N, ve Ramasamy, R. (2023). Evaluation and management of male genital tract infections in the setting of male infertility: an updated review. Current Opinion in Urology. 2023 May 1;33(3):180-186. https://doi.org/10.1097/MOU.0000000000001081
Rooney, K. L., ve Domar, A. D. (2018). The relationship between stress and infertility. Dialogues in Clinical Neuroscience, 20(1), 41–47. https://doi.org/10.31887/DCNS.2018.20.1/klrooney
Sanchez, A. M., Vanni, V. S., Bartiromo, L., Papaleo, E., Zilberberg, E., Candiani, M., Orvieto, R., ve Viganò, P. (2017). Is the oocyte quality affected by endometriosis? A review of the literature. Journal of ovarian research, 10(1), 43. https://doi.org/10.1186/s13048-017-0341-4
Sharma, R., Harlev, A., Agarwal, A., ve Esteves, S. C. (2016). Cigarette smoking and semen quality: A new meta-analysis examining the effect of the 2010 World Health Organization laboratory methods for the examination of human semen. European Urology, 70(4), 635–645. https://doi.org/10.1016/j.eururo.2016.04.010
Silvestris, E., de Pergola, G., Rosania, R., & Loverro, G. (2018). Obesity as disruptor of the female fertility. Reproductive Biology and Endocrinology, 16, 22. https://doi.org/10.1186/s12958-018-0336-z
Strandell, A. (2000). The influence of hydrosalpinx on IVF and embryo transfer: A review. Human Reproduction Update, 6(4), 387–395. https://doi.org/10.1093/humupd/6.4.387
Su, H. I., Lacchetti, C., Letourneau, J., Partridge, A. H., Qamar, R., Quinn, G. P., Reinecke, J., Smith, J. F., Tesch, M., Wallace, W. H., Wang, E. T., & Loren, A. W. (2025). Fertility preservation in people with cancer: ASCO guideline update. Journal of Clinical Oncology, 43(12), 1488–1515. https://doi.org/10.1200/JCO-24-02782
Sun, H., Gong, T. T., Jiang, Y. T., Zhang, S., Zhao, Y. H., ve Wu, Q. J. (2019). Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990–2017. Aging, 11(23), 10952–10963. https://doi.org/10.18632/aging.102497
Sun, B. S., ve Yeh, J. Y. (2022). Non-invasive and mechanism-based molecular assessment of endometrial receptivity during the window of implantation: Current concepts and future prospective testing directions. Frontiers in Reproductive Health, 4, 863173. https://doi.org/10.3389/frph.2022.863173
Tal, R., Seifer, D. B. (2017). Ovarian reserve testing: A user's guide. American Journal of Obstetrics and Gynecology, 217(2), 129–140. https://doi.org/10.1016/j.ajog.2017.02.027
Teede, H. J., Tay, C. T., Laven, J. J. E., Dokras, A., Moran, L. J., Piltonen, T. T., Costello, M. F., Boivin, J., Redman, L. M., Boyle, J. A., Norman, R. J., Mousa, A., ve Joham, A. E. (2023). Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Human Reproduction, 38(9), 1655–1679. https://doi.org/10.1093/humrep/dead156
Tomassetti, C., Johnson, N. P., Petrozza, J., ve ark. (2021). An international terminology for endometriosis: A consensus statement. Human Reproduction Open, 2021(4), hoab032. https://doi.org/10.1093/hropen/hoab032
Vander Borght, M., ve Wyns, C. (2018). Fertility and infertility: Definition and epidemiology. Clinical Biochemistry, 62, 2–10. https://doi.org/10.1016/j.clinbiochem.2018.03.012
Vessa, B., Perlman, B., McGovern, P. G., ve Morelli, S. S. (2022). Endocrine disruptors and female fertility: A review of pesticide and plasticizer effects. FveS Reports, 3(2), 86–90. https://doi.org/10.1016/j.xfre.2022.04.003
Ying, L. Y., Wu, L. H., ve Loke, A. Y. (2016). Gender differences in experiences with and adjustments to infertility: A literature review. International Journal of Nursing Studies, 56, 123–133. https://doi.org/10.1016/j.ijnurstu.2015.10.004
World Health Organization. (2021). WHO laboratory manual for the examination and processing of human semen (6th ed.). World Health Organization. Retrieved July 29, 2026, from https://www.who.int/publications/i/item/9789240030787
World Health Organization-WHO. (2023). Infertility. Retrieved July 29, 2026, from https://www.who.int/news-room/fact-sheets/detail/infertility
AKSÜT AKÇAY, E. & ÇAKIR, D. (2026). İNFERTİLİTEDE GÜNCEL YAKLAŞIMLAR VE PSİKOSOSYAL SÜREÇLER. In GÜÇLÜ CİHAN, E. (Ed.), Kadın Sağlığında Güncel Yaklaşımlar ve Disiplinlerarası Perspektifler (pp. 153-179). Vizetek Yayıncılık. https://doi.org/10.54637/vizetek.9786253824013
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